Research based on the advanced absorption of crucial nutrients

EASE Joint & Hip for Osteoarthritis

Research Findings:

Green Gruff Veterinary increased the absorption of glucosamine into the blood plasma and synovial fluid more effectively than glucosamine alone.

Previous efforts to use glucosamine to reduce symptoms associated with pain and lack of mobility due to osteoarthritis have been thwarted by lack of sustained bioavailability, and lack of sufficient amount of glucosamine in the target area, the synovial fluid.

We conducted a clinical trial to understand how Green Gruff Veterinary increases the absorption of glucosamine into the plasma and synovial fluid. After 8 hours, the concentration of glucosamine in the blood plasma was 207% greater in the experimental group than the control group. There was also a higher concentration of glucosamine in the synovial fluid of the experimental group than the control group. View the research here.

Methodology & Timeline

We partnered with Companion Sciences to conduct a series of scientific studies to understand how CBD affects glucosamine absorption, to determine how Green Gruff Veterinary increases glucosamine absorption compared to glucosamine alone, and to assess the safety and tolerability of the Green Gruff Veterinary formulation.

1

Phase I

  • Objective: Show that CBD increases glucosamine absorption into the synovial fluid (rats).
  • Status: Completed.
  • Outcome: CBD increased glucosamine penetration from the plasma to the synovial fluid.
2

Phase II

  • Objective: Show that the Green Gruff Veterinary formulation improves the absorption of glucosamine into the synovial fluid more effectively than glucosamine alone (rats).
  • Status: Completed.
  • Outcome: A higher glucosamine concentration in the synovial fluid was observed in rats administered Green Gruff Veterinary compared to those administered glucosamine alone. View Phase II research here.
3

Phase III

  • Objective: Conduct a clinical trial to prove the safety and efficacy of Green Gruff Veterinary in dogs and show that it can improve signs of OA relative to glucosamine alone.
  • Status: Scheduled Q1 2023.
  • Outcome: Expected Q3 2023.

Learn the scientific research used to formulate and bring EASE Joint & Hip to the professional veterinary market

Green Gruff EASE Joint & Hip supplements with a full 5mg of broad-spectrum CBD included in each chew

If you're interested in offering Green Gruff EASE Joint & Hip supplements at your practice this is the place to start.